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- Title
Algorithms for a Single Hormone Closed-Loop Artificial Pancreas: Challenges Pertinent to Chemical Process Operations and Control.
- Authors
Bequette, B. Wayne; Cameron, Faye; Baysal, Nihat; Howsmon, Daniel P.; Buckingham, Bruce A.; Maahs, David M.; Levy, Carol J.
- Abstract
The development of a closed-loop artificial pancreas to regulate the blood glucose concentration of individuals with type 1 diabetes has been a focused area of research for over 50 years, with rapid progress during the past decade. The daily control challenges faced by someone with type 1 diabetes include asymmetric objectives and risks, and one-sided manipulated input action with frequent relatively fast disturbances. The major automation steps toward a closed-loop artificial pancreas include (i) monitoring and overnight alarms for hypoglycemia (low blood glucose); (ii) overnight low glucose suspend (LGS) systems to prevent hypoglycemia; and (iii) fully closed-loop systems that adjust insulin (and perhaps glucagon) to maintain desired blood glucose levels day and night. We focus on the steps that we used to develop and test a probabilistic, risk-based, model predictive control strategy for a fully closed-loop artificial pancreas. We complete the paper by discussing ramifications of lessons learned for chemical process systems applications.
- Subjects
ARTIFICIAL pancreases; BLOOD sugar analysis; PREDICTIVE control systems; CLOSED loop systems; HORMONES; ALGORITHMS
- Publication
Processes, 2016, Vol 4, Issue 4, p39
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr4040039