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- Title
Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis.
- Authors
Tabra, Samar Abdalhamed; Abu-Zaid, Mohammed Hassan; Elsharaby, Radwa Mahmoud; Maria, Dina; ElMiedany, Samah
- Abstract
Background: Psoriatic arthritis (PsA) is a chronic multi-domains autoimmune inflammatory disorder. Patients with PsA have a significant prevalence of cardiovascular affection. Upregulated Interleukin-34 (IL-34) has been seen in many autoimmune disorders, and also in atherosclerotic plaques. The aim of this observational case–control study was to evaluate the serum levels of il-34 in PsA patients and correlate between its level and disease activity, and subclinical cardiovascular affection. Results: In this study, there were 70 PsA patients and 70 healthy volunteers, 43 patients were on Methotrexate, 6 on sulfasalazine, while 40 patients were on biological therapy either monotherapy or in combination with DMARDs. There were significant differences between PsA patients and controls in ESR, high sensitivity-CRP, total lipid profile, and IL-34 levels (p < 0.05) while there were no significant differences regarding Echo and ECG results. Also, we found that there was significant elevation in DAPSA score, hs-CRP, IL-34, and cIMT in the active patients when we compared them with inactive patients. IL-34 had significant positive correlations with DAPSA score, hs-CRP, and cIMT (r = 0.654, 0.579, and 0.658 respectively). Conclusion: Serum interleukin-34 is an important marker in PsA as its levels were elevated in PsA patients and were correlated with disease activity and subclinical cardiovascular affection.
- Subjects
ATHEROSCLEROSIS risk factors; LIPID analysis; INTERLEUKINS; PSORIATIC arthritis; C-reactive protein; CAROTID artery; BIOMARKERS; SCIENTIFIC observation; COMBINATION drug therapy; MULTIPLE regression analysis; CASE-control method; CLINICS; REGRESSION analysis; METHOTREXATE; BIOTHERAPY; ANTIRHEUMATIC agents; IMMUNOASSAY; BLOOD sedimentation; ELECTROCARDIOGRAPHY; DESCRIPTIVE statistics; DATA analysis software; SULFONAMIDES
- Publication
Egyptian Rheumatology & Rehabilitation, 2023, Vol 50, Issue 1, p1
- ISSN
1110-161X
- Publication type
Article
- DOI
10.1186/s43166-023-00183-z