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- Title
In Vitro Anticancer Properties of Copper Metallodendrimers.
- Authors
Hołota, Marcin; Magiera, Jakub; Michlewska, Sylwia; Kubczak, Małgorzata; Sanz del Olmo, Natalia; García-Gallego, Sandra; Ortega, Paula; de la Mata, Francisco Javier; Ionov, Maksim; Bryszewska, Maria
- Abstract
Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.
- Subjects
SURFACE charges; FLUORESCENCE anisotropy; TRANSMISSION electron microscopy; DRUG carriers; CIRCULAR dichroism; ZETA potential
- Publication
Biomolecules (2218-273X), 2019, Vol 9, Issue 4, p155
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom9040155