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- Title
Safety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL).
- Authors
Kołkowski, Karol; Sokołowska-Wojdyło, Małgorzata
- Abstract
Microenvironment has a significant impact on the pathogenesis of cutaneous T-cell lymphoma (CTCL), especially in the context of new emerging biologic therapies. Our aim was to review the literature on interleukins 12, 17, 23 and tumour necrosis factor-a in mycosis fungoides in order to clarify the safety of using biologics in the treatment of psoriasis. Our analysis suggests that these drugs may have an impact on the progression of CTCL. Concluding, in case of uncertain psoriatic lesions, a biopsy followed by pathologic examination should exclude the possibility of co-existence of a primary cutaneous lymphoma before administration of therapies affecting cytokine profiles.
- Subjects
CUTANEOUS T-cell lymphoma; MYCOSIS fungoides; INTERLEUKIN-12; INTERLEUKIN-17; TUMOR necrosis factors
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2021, Vol 38, Issue 6, p953
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/ada.2021.107553