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- Title
Misaligned sequencing reads from the GNAQ-pseudogene locus may yield GNAQ artefact variants.
- Authors
Lim, Jing Quan; Lim, Soon Thye; Ong, Choon Kiat
- Abstract
In an analysis for somatic mutations, the germline mutations would be subtracted from the tumor mutations. As such, NGS reads that were representing these SNPs would be misaligned to I GNAQ i instead and be misinterpreted for somatic mutations encoding for p.T96S and p.Y101X instead. B arising from b Zhaoming Li et al. I Nature Communications i https://doi.org/10.1038/s41467-019-12032-9 (2019) Next-generation sequencing (NGS) has enabled the interrogation of DNA sequences at an unprecedented fashion.
- Subjects
SOMATIC mutation; HUMAN genetic variation; NUCLEOTIDE sequencing; LOCUS (Genetics); CYTOTOXIC T cells
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-28115-z