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- Title
Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model.
- Authors
Herrera-Calderon, Oscar; Bulege-Gutiérrez, Wilfredo; Javier-Silva, Luz Alexandra; Iparraguirre-Meza, Melva; Guillermo Sanchez-Araujo, Victor; Julia Melgar-Merino, Elizabeth; Tinco-Jayo, Johnny Aldo; Santiago Almeida-Galindo, José; Pari-Olarte, Josefa Bertha
- Abstract
Background: Tanacetum parthenium (L.) Sch Bip known as "santa maría" (Asteraceae family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. Objective: The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of T. parthenium Material and Methods: Leaves and flowers of T. parthenium were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method. Results: Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC50 showed in leaves and flowers extract 452.10 ± 10.2 µg/mL and 270.70 ± 20.6 µg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/Kg than flower extract. Conclusions: The ethanolic extract of flowers of T. parthenium showed a high antioxidant activity and antinociceptive effect in mice.
- Subjects
PERU; PHYTOCHEMICALS; STEROID saponins; ETHANOL; PHENOLS; OXIDANT status; FLOWER shows; ANTIOXIDANTS; SAPONINS
- Publication
Pharmacognosy Journal, 2023, Vol 15, Issue 3, p435
- ISSN
0975-3575
- Publication type
Article
- DOI
10.5530/pj.2023.15.97