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- Title
Amygdala Size Reduction Is Associated with Memory Deficits in Complicated Hereditary Spastic Paraparesis: An MRI Study.
- Authors
Pinkhardt, Elmar H.; Sperfeld, Anne-D.; Uttner, Ingo; Ludolph, Albert C.; Kassubek, Jan
- Abstract
Neuroimaging findings in hereditary spastic paraparesis (HSP), especially in complicated HSP (cHSP), are heterogenous. This study aimed to investigate possible in vivo morphological alterations of the whole brain and the amygdala in cHSP as a correlate of cognitive impairment in contrast to pure variants (pHSP). Amygdalar and whole brain volumes of 33 HSP patients (21 pHSP and 12 cHSP) were measured using three-dimensional magnetic resonance imaging (MRI) data sets by region of interest-based volumetry. A neuropsychological test battery was also performed. A significant reduction in whole brain volume compared with the controls, as well as significant correlations with reduced amygdalar volume and a worse neuropsychological test performance was observed only in cHSP patients. Our findings of disproportional amygdalar atrophy only in cHSP substantiate the association of morphologically assessable cerebral degeneration with cognitive impairment in cHSP. Copyright © 2010 S. Karger AG, Basel
- Subjects
MAGNETIC resonance imaging of the brain; PARAPARESIS; AMYGDALOID body; SPASTIC paralysis; GENETIC disorders; INTELLECTUAL disabilities; NEUROPSYCHOLOGICAL tests
- Publication
European Neurology, 2010, Vol 64, Issue 2, p117
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000316773