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- Title
Does COVID-19 affect thyroid more than non-COVID-19 infections? A retrospective study.
- Authors
Ucal, Yasemin; Serdar, Muhittin; Karpuzoğlu, Hande; Yurttutan Uyar, Neval; Kilercik, Meltem; Serteser, Mustafa; Ozpinar, Aysel
- Abstract
To evaluate the thyroid hormone levels and infection markers in COVID-19 patients and compare them to those in non-COVID-19 patients with infection in a large retrospective dataset. In this study, thyroid-stimulating hormone (TSH), thyroid hormones (free T3 and free T4), and several infection markers were reviewed. The study group was divided into three groups that had no thyroid-related disorders: control patients (Group 0; n=7,981), COVID-19 patients (Group 1; n=222), and non-COVID-19 patients with infection (Group 2; n=477). The data were assessed for correlation and group comparisons. There was a reduction in median (25th–75th percentile) fT3 levels in COVID-19 patients 4.17 pmol/L (3.46–4.85) compared to non-COVID-19 patients with infection 4.65 pmol/L (4.12–5.15), p<0.0001. We detected a negative correlation between fT3 and neutrophil-to-lymphocyte ratio (NLR) in Group 1 (r=−0.534) and Group 2 (r=−0.346) (p<0.0001), indicating a relatively stronger link between fT3 and NLR in COVID-19 patients than non-COVID-19 patients with infection. Additionally, the fT3 levels remained significantly different between study groups when the model was adjusted for age, gender, and infection markers. COVID-19 and non-COVID-19 infections are associated with low fT3 levels, which likely represent the suppression of the hypothalamic-pituitary-thyroid axis from non-thyroidal illness syndrome.
- Subjects
THYROID gland; COVID-19; HYPOTHALAMIC-pituitary-thyroid axis; NEUTROPHIL lymphocyte ratio; THYROID hormones; INFECTION
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2024, Vol 49, Issue 2, p227
- ISSN
0250-4685
- Publication type
Article
- DOI
10.1515/tjb-2023-0113