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- Title
External Validation of the Lupus Impact Tracker in a Southeastern US Longitudinal Cohort With Systemic Lupus Erythematosus.
- Authors
Brandt, Jennifer E.; Drenkard, Cristina; Kan, Hong; Bao, Gaobin; Dunlop-Thomas, Charmayne; Pobiner, Bonnie; Chang, David J.; Jolly, Meenakshi; Lim, S. Sam
- Abstract
<bold>Objective: </bold>To examine the external validity of the Lupus Impact Tracker (LIT), a systemic lupus erythematosus (SLE)-specific, health-related quality of life (HRQoL) tool in a population-based cohort of patients with SLE in Atlanta, Georgia. We modeled the association of LIT scores with patient-reported measures of SLE activity (Systemic Lupus Activity Questionnaire [SLAQ]) and organ damage (self-administered Brief Index of Lupus Damage [SA-BILD]). We investigated the association of LIT scores with general HRQoL using the Short Form 12 (SF-12).<bold>Methods: </bold>Correlation, multivariable regression, and longitudinal analyses using general linear modeling with fixed effects were performed to investigate the association between the LIT and patient-reported disease activity (SLAQ); patient-reported disease damage (SA-BILD); mental health (mental component summary [MCS] of the SF-12); and physical health (physical component summary [PCS] of the SF-12). Demographic trends related to the LIT were also assessed using cross-sectional analysis.<bold>Results: </bold>The LIT was significantly associated with disease activity (SLAQ), organ damage (SA-BILD), MCS scores, and PCS scores in both adjusted and unadjusted regression analysis (P < 0.0001). Longitudinal analysis demonstrated a significant association between the LIT and disease activity (SLAQ), MCS scores, and PCS scores (P < 0.0001), but not organ damage (SA-BILD).<bold>Conclusion: </bold>The LIT is a simple, patient-centered tool that can be used to assess HRQoL in patients with SLE. This study provides external validity of the LIT in a population-based cohort with a large number of African American patients with a relatively high disease burden.
- Subjects
GEORGIA; SOUTHERN States; MENTAL health; QUALITY of life; SYSTEMIC lupus erythematosus diagnosis; SURVEYS; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; QUESTIONNAIRES; RESEARCH; SYSTEMIC lupus erythematosus; EVALUATION research; ACQUISITION of data; CROSS-sectional method; STANDARDS; PSYCHOLOGY
- Publication
Arthritis Care & Research, 2017, Vol 69, Issue 6, p842
- ISSN
2151-464X
- Publication type
journal article
- DOI
10.1002/acr.23009