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- Title
P-values and decision-making: discussion of 'Limitations of empirical calibration of p-values using observational data'.
- Authors
Franklin, Jessica M.
- Abstract
Gruber and Tchetgen Tchetgen bring up many important limitations of p-value calibration as applied to the assessment of the safety and effectiveness of medications in secondary administrative data. In this discussion, I further examine the role of study design and selection of comparators in interpreting p-value calibration results, and we consider the advantages and disadvantages of automation in the epidemiology of medications, including p-value calibration. Copyright © 2016 John Wiley & Sons, Ltd.
- Subjects
CALIBRATION; DECISION making; DRUG side effects; EXPERIMENTAL design; STATISTICS; DATA analysis
- Publication
Statistics in Medicine, 2016, Vol 35, Issue 22, p3889
- ISSN
0277-6715
- Publication type
journal article
- DOI
10.1002/sim.6984