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- Title
A Comprehensive Review and Perspective on Natural Sources as Dipeptidyl Peptidase-4 Inhibitors for Management of Diabetes.
- Authors
Shaikh, Sibhghatulla; Lee, Eun-Ju; Ahmad, Khurshid; Ahmad, Syed-Sayeed; Lim, Jeong-Ho; Choi, Inho
- Abstract
Type 2 diabetes mellitus (T2DM) is an increasing global public health problem, and its prevalence is expected to rise in coming decades. Dipeptidyl peptidase-4 (DPP-4) is a therapeutic target for the management of T2DM, and its inhibitors prevent the degradation of glucose-dependent insulinotropic peptide and glucagon-like peptide 1, and thus, maintain their endogenous levels and lower blood glucose levels. Various medicinal plant extracts and isolated bioactive compounds exhibit DPP-4 inhibitory activity. In this review, we discussed different natural sources that have been shown to have anti-diabetic efficacy with a particular emphasis on DPP-4 inhibition. Furthermore, the effect of DPP-4 inhibition on pancreatic beta cell function, skeletal muscle function, and the glucose-lowering mechanisms were also discussed. We believe that scientists looking for novel compounds with therapeutic promise against T2DM will be able to develop antidiabetic drugs using these natural sources.
- Subjects
CD26 antigen; TYPE 2 diabetes; GLUCAGON-like peptide 1; GASTRIC inhibitory polypeptide; PANCREATIC beta cells; GLUCAGON-like peptide-1 receptor
- Publication
Pharmaceuticals (14248247), 2021, Vol 14, Issue 6, p591
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph14060591