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- Title
TRANSFUSION COMPLICATIONS In vivo PLT increments after transfusions of WBC-reduced PLT concentrates stored for up to 7 days.
- Authors
Dijlcstra-Tiekstra, M. J.; Pietersz, R. N. I.; Hendriks, E. C. M.; Reesink, H. W.; Huijgens, P. C.
- Abstract
Bacterial screening and improvement of storage conditions of leukoreduced PLT concentrates (LR-PCs) allows extension of their storage period from 5 to 7 days. For in vitro studies, 40 LR-PCs made from five buffy coats and plasma were studied for 8 days. For in vivo studies, routinely produced LR-PCs stored for 2 to 7 days after blood collection were administered to clinically stable thrombocytopenic patients. CI1 h was calculated after 353 transfusions (67 patients), and CCI1 h, after 195 transfu-sions (55 patients), with pretransfusion PLT counts of not greater than 20 × 109 per mL. Storage experiments showed that the pH of LR-PCs remained greater than 6.8 for 8 days, provided that the PLT concentration was less than 1.3 × 109 per mL. Routinely produced LR-PCs had a volume of 282 ± 15 mL (n = 10,193) and contained 329 × 109± 40 × 109 PLTs (n = 3467). For 7-day-old LR-PCs, 76 of 78 (97%) of the transfusions resulted in a CI1 h of at least 10 and 37 of 39 (95%) in a CCI1 h of at least 7.5, which indicated levels for successfulness. Mean ± SE values of CI1 h and CCI1 h of 7-day-old LR-PCs were 28.7 ± 2.3 (n = 78) and 19.0 ± 2.0 (n = 39), respectively. No significant differences were observed between 5- and 7-day-old LR-PCs transfused with respect to CI1 h and CCI1 h values. In vitro and in vivo studies showed that LR-PCs can be stored for up to 7 days with excellent clinical results, provided that they are routinely screened for bacterial contamination.
- Subjects
BLOOD transfusion reaction; LEUCOCYTES; MICROBIAL contamination; BLOOD collection; BLOOD transfusion; THROMBOCYTOPENIA; PATIENTS; PREVENTION
- Publication
Transfusion, 2004, Vol 44, Issue 3, p330
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/j.1537-2995.2003.00622.x