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- Title
Plasma Levels of Inflammatory Biomarkers in Peripheral Arterial Disease.
- Authors
Signorelli, Salvatore Santo; Anzaldi, Massimiliano; Libra, Massimo; Navolanic, Patrick M.; Malaponte, Graziella; Mangano, Katia; Quattrocchi, Cinzia; Di Marco, Roberto; Fiore, Valerio; Neri, Sergio
- Abstract
Previous research analyzed the level of plasma inflammatory markers in patients with coronary disease, but very few studies have evaluated these markers in patients with peripheral arterial disease (PAD). The objective of this study was to investigate the plasma levels of inflammatory markers in patients with PAD and in healthy controls. The following plasma levels of biomarkers were measured in 80 patients with PAD (mean age 68 ± 5 years) and in 72 healthy participants (mean age 67 ± 6 years): interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), L-selectin (LS), neopterin (N), P-selectin (PS), E-selectin (ES), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and matrix metalloproteinase 2 (MMP-2), and 9 (MMP-9). Significantly higher levels of IL-6 (P < .001), TNF-α (P < .0001), ES (P < .0001), LS (P < .0001), PS (P < .0001), ICAM-1 (P < .001), VCAM-1 (P < .001), N (P < .001), MMP-2 (P < .001), and MMP-9 (P < .005) were found in the patients with PAD. Patients with PAD show a inflammation marker profile different from that of control participants. Reducing the high plasma levels of inflammatory markers could be a new therapeutic approach both for the prevention and the treatment of PAD.
- Subjects
ITALY; BIOMARKERS; CELL adhesion molecules; INFLAMMATION; INTERLEUKINS; LONGITUDINAL method; PERIPHERAL vascular diseases; PROBABILITY theory; PROTEOLYTIC enzymes; REGRESSION analysis; STATISTICAL hypothesis testing; T-test (Statistics); TUMOR necrosis factors; ANKLE brachial index; DATA analysis software; ONE-way analysis of variance
- Publication
Angiology, 2016, Vol 67, Issue 9, p870
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319716633339