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- Title
Plasma Concentrations of Risperidone and Olanzapine during Coadministration with Oxcarbazepine.
- Authors
Muscatello, Maria Rosaria; Pacetti, Monica; Cacciola, Massimo; La Torre, Diletta; Zoccali, Rocco; D'Arrigo, Concetta; Migliardi, Gaetana; Spina, Edoardo
- Abstract
Purpose:Oxcarbazepine (OZC) is a second-generation antiepileptic drug (AED) that also may be used as a mood stabilizer. Unlike carbamazepine (CBZ), which is an inducer of the cytochrome P-450 isoforms and may accelerate the elimination of several therapeutic agents, OXC seems to have only a modest inducing action. The aim of this investigation was to evaluate the effect of a treatment with OXC on plasma concentrations of the new antipsychotics risperidone and olanzapine.Methods:OXC, at a dosage of 900–1,200 mg/day, was administered for 5 consecutive weeks to 25 outpatients, 10 men and 15 women, aged 25 to 64 years, with bipolar or schizoaffective disorder. Twelve patients were stabilized on risperidone therapy (2–6 mg/day) and 13 on olanzapine (5–20 mg/day). Steady-state plasma concentrations of risperidone and its active metabolite 9-hydroxyrisperidone (9-OH-risperidone) and olanzapine were measured by high-pressure liquid chromatography (HPLC) before addition of OXC and after 5 weeks from the start of adjunctive treatment.Results:OXC caused only minimal and no significant changes in the mean plasma levels of risperidone (from 5.6± 3.6 ng/ml at baseline to 4.8± 2.6 ng/ml at week 5), 9-OH-risperidone (from 23.6± 7.5 to 24.7± 7.4 ng/ml), and olanzapine (from 26.5± 5.7 ng/ml at baseline to 27.8± 5.1 ng/ml). OXC coadministration with either risperidone or olanzapine was well tolerated.Conclusions:Our findings indicate that OXC does not affect the elimination of risperidone and olanzapine, thus confirming its weak inducing effect on hepatic drug-metabolizing enzymes.
- Subjects
SCHIZOAFFECTIVE disorders; PATHOLOGICAL psychology; THERAPEUTICS; RISPERIDONE; OLANZAPINE; ANTIPSYCHOTIC agents; CYTOCHROME P-450
- Publication
Epilepsia (Series 4), 2005, Vol 46, Issue 5, p771
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/j.1528-1167.2005.71104.x