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- Title
Magnetic Resonance Spectroscopy and Histopathological Findings in Temporal Lobe Epilepsy.
- Authors
Stefan, H.; Feichtinger, M.; Pauli, E.; Schafer, I.; Eberhardt, K.W.; Kasper, B.S.; Hopp, P.; Buchfelder, M.; Huk, J.; Paulus, W.
- Abstract
Summary: Purpose: In some patients with temporal lobe epilepsy, histopathological evaluation of resected brain tissue after surgical treatment may reveal several features indicative of discrete cortical malformations. We sought to determine whether these histopathological features were accompanied by hippocampal changes detectable preoperatively by proton mag-netic resonance (MR) spectroscopy and to evaluate their rela-tionship with postoperative outcome. Methods: In 25 consecutive temporal lobe epilepsy patients who were scheduled for surgical treatment, MR spectroscopy was performed, and resected brain tissue was analyzed histo-pathologically for the presence of discrete cortical malforma-tions (e.g., microdysgenesis). Outcome was assessed in all pa-tients with an average postoperative period of 26 months. Results: In 13 patients, we found subtle, histopathologically detectable signs of cortical malformation: 6 of them with con-.
- Subjects
TEMPORAL lobe epilepsy; PROTON magnetic resonance spectroscopy; BRAIN; HISTOPATHOLOGY
- Publication
Epilepsia (Series 4), 2001, Vol 42, Issue 1, p41
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1046/j.1528-1157.2001.080873.x