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- Title
Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study.
- Authors
Farì, Giacomo; Megna, Marisa; Scacco, Salvatore; Ranieri, Maurizio; Raele, Maria Vittoria; Chiaia Noya, Enrica; Macchiarola, Dario; Bianchi, Francesco Paolo; Carati, Davide; Panico, Simona; Di Campi, Eleonora; Gnoni, Antonio; Scacco, Venera; Inchingolo, Alessio Danilo; Qorri, Erda; Scarano, Antonio; Rapone, Biagio
- Abstract
Background and Objectives: Nutraceuticals are gaining more and more importance as a knee osteoarthritis (KOA) complementary treatment. Among nutraceuticals, hemp seed oil and terpenes are proving to be very useful as therapeutic support for many chronic diseases, but there are still few studies regarding their effectiveness for treating KOA, both in combination and separately. The aim of this study is thus to compare the effect of two dietary supplements, both containing hemp seed oil, but of which only one also contains terpenes, in relieving pain and improving joint function in patients suffering from KOA. Materials and Methods: Thirty-eight patients were recruited and divided into two groups. The control group underwent a 45 day treatment with a hemp seed oil-based dietary supplement, while the treatment group assumed a hemp seed oil and terpenes dietary supplement for the same period. Patients were evaluated at the enrollment (T0) and at the end of treatment (T1). Outcome measures were: Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), Short-Form-12 (SF-12), Knee Injury Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS). Results: All outcome measures improved at T1 in both groups, but NRS, KOOS and OKS had a greater significant improvement in the treatment group only. Conclusions: Hemp seed oil and terpenes resulted a more effective integrative treatment option in KOA, improving joint pain and function and representing a good complementary option for patients suffering from osteoarthritis.
- Subjects
KNEE osteoarthritis; OILSEEDS; JOINT pain; MYRCENE; HEMP
- Publication
Medicina (1010660X), 2023, Vol 59, Issue 2, p191
- ISSN
1010-660X
- Publication type
Article
- DOI
10.3390/medicina59020191