We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
- Authors
Akatsuki Kokaze; Mamoru Ishikawa; Naomi Matsunaga; Kanae Karita; Masao Yoshida; Naoki Shimada; Tadahiro Ohtsu; Takako Shirasawa; Hirotaka Ochiai; Masao Satoh; Masayasu Hashimoto; Hiromi Hoshino; Yutaka Takashima
- Abstract
Background: Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects. Methods: A total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted. Results: For subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily. Conclusions: The present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
- Subjects
MITOCHONDRIAL DNA; GENETIC polymorphisms; SMOKING; DYSLIPIDEMIA; BLOOD lipoprotein metabolism disorders
- Publication
Lipids in Health & Disease, 2012, Vol 11, Issue 1, p97
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/1476-511X-11-97