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- Title
To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe<sup>III</sup>-Porphyrin Center.
- Authors
Tseng, Yu ‐ Ting; Chen, Chien ‐ Hong; Lin, Jing ‐ Yu; Li, Bing ‐ Han; Lu, Yu ‐ Huan; Lin, Chia ‐ Her; Chen, Hsin ‐ Tsung; Weng, Tsu ‐ Chien; Sokaras, Dimosthenes; Chen, Huang ‐ Yeh; Soo, Yun ‐ Liang; Lu, Tsai ‐ Te
- Abstract
A positive myocardial inotropic effect achieved using HNO/NO−, compared with NO⋅, triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies.
- Subjects
NITROXYL; CHEMICAL biology; PHARMACEUTICAL research; BIOLOGICAL research; PORPHYRINS
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 49, p17570
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201503176