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- Title
Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu<sub>2−</sub><sub>x</sub>Se Nanoparticles to Enhance Anti‐Tumor Immunity (Adv. Funct. Mater. 12/2022).
- Authors
Zheng, Yanhui; Han, Yaobao; Wang, Tingting; Liu, Hanghang; Sun, Qiao; Hu, Shijun; Chen, Jianquan; Li, Zhen
- Abstract
In the article "Reprogramming Tumor-Associated Macrophages," Zhen Li and colleagues discuss their findings on the use of ultra-small Cu2-xSe nanoparticles to reprogram tumor-associated macrophages (TAMs) and enhance anti-tumor immunity. The nanoparticles were found to effectively polarize TAMs from a tumor-supportive M2 phenotype to an anti-tumor M1 phenotype through a novel ROS-TRAF6-IRF5-IL-23 signaling pathway. This mechanism differs from the classic ROS-NF-κB-iNOS pathway. The study provides valuable insights into potential strategies for boosting anti-tumor immunity.
- Subjects
MACROPHAGES; IMMUNITY; TUMOR necrosis factors; NANOPARTICLES
- Publication
Advanced Functional Materials, 2022, Vol 32, Issue 12, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202108971