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- Title
Design of Au/SPIO composite nanoparticle for facile and biocompatible surface functionalization via Au-S bond.
- Authors
Seino, Satoshi; Shibata, Yujin; Yamanaka, Masayuki; Nakagawa, Takashi; Mukai, Yohei; Nakagawa, Shinsaku; Yamamoto, Takao
- Abstract
Immobilization of Au nanoparticles on super-paramagnetic iron-oxide (SPIO) enables facile and biocompatible surface functionalization via Au-S bond. Au/SPIO composite nanoparticle is easily modified by thiol-modified polyethylene glycol (PEG-SH), and they are successfully applied on MR tumor imaging. However, its large hydrodynamic size (~150 nm) still causes the accumulation to liver in vivo. In this study, we controlled the hydrodynamic size of Au/SPIO by testing different raw SPIOs and stabilizing polymers. As the best candidate, Au/Molday-ION which was synthesized from Molday-ION and polyvinyl alcohol comprised the hydrodynamic size of 56 nm. Moreover, PEGylated Au/Molday-ION showed excellent dispersibility in blood serum, with the hydrodynamic size of 65 nm. This surface functionalization strategy is effective for the constructions of magnetic nanocarriers for in vivo applications.
- Subjects
SUPERPARAMAGNETIC materials; IRON oxide nanoparticles; BIOCOMPATIBILITY; POLYETHYLENE glycol; RADIOCHEMISTRY; HYDRODYNAMICS; POLYVINYL alcohol
- Publication
Journal of Nanoparticle Research, 2013, Vol 15, Issue 1, p1
- ISSN
1388-0764
- Publication type
Article
- DOI
10.1007/s11051-012-1305-7