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- Title
Hypotensive effects of captopril on physical properties of the arterial system in young and adult rats.
- Authors
Chang, Kuo-Chu; Peng, Ying-I; Tsai, Yuan-Feen; Tseng, Yung-Zu; Chen, Hsing-I
- Abstract
We determined the acute effects of the angiotension converting enzyme inhibitor captopril on the arterial mechanics in rats at different ages, based on the exponentially tapered T-tube model. Male Wistar-Kyoto rats aged 4 and 12 months were individually referred to as young (n = 8) and adult rats (n = 8) and were anesthetized and thoractomized. The pulsatile aortic pressure and flow signals before and after the administration of captopril (20 mg/kg, i.p.) were measured by a high-fidelity pressure sensor and an electromagnetic flow probe, respectively. In each age group, captopril showed little change in basal heart rate as well as cardiac output. However, captopril produced a drop of 15% in mean aortic pressure in young and a fall of 12% in adult rats. In addition, captopril reduced total peripheral resistance by 21% in young and by 23% in adult animals. As for the pulsatile nature of the arterial system, captopril had increased wave transit time of the lower body circulation of 10% in young and of 12% in adult rats. By contrast, captopril reduced wave reflection factor by 22% in young and by 25% in adult animals. In conclusion, the converting enzyme inhibitor captopril has a stiffness-decreasing effect on Windkessel vessels and a dilated effect on resistance arterioles in either young or adult rats. No age dependence of vascular response and reflex tachycardia to captopril has been found in rats between 4 and 12 months.
- Subjects
HORMONE antagonists; ADRENERGIC alpha blockers; PROLINE; CAPTOPRIL; HEART beat; CARDIAC output
- Publication
Biogerontology, 2001, Vol 2, Issue 1, p45
- ISSN
1389-5729
- Publication type
Article
- DOI
10.1023/A:1010017203981