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- Title
IRS-2 pathways integrate female reproduction and energy homeostasis.
- Authors
Burks, Deborah J.; Font de Mora, Jaime; Schubert, Markus; Withers, Dominic J.; Myers, Martin G.; Towery, Heather H.; Altamuro, Shari L.; Flint, Carrie L.; White, Morris F.
- Abstract
Shows that deletion of insulin receptor substrate-2, a component of the insulin/insulin-like growth factor-1 signalling cascade, causes female infertility in mammals. Findings, which indicate that insulin together with leptin and other neuropeptides may modulate hypothalamic control of appetite and reproductive endocrinology; Identification of an evolutionarily conserved mechanism that regulates both reproduction and energy homeostasis.
- Subjects
INSULIN; FEMALE infertility; REPRODUCTION; METABOLISM; PHYSIOLOGY
- Publication
Nature, 2000, Vol 407, Issue 6802, p377
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35030105