We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Experimental evolution of protein-protein interaction networks.
- Authors
KAÇAR, Betül; GAUCHER, Eric A.
- Abstract
The modern synthesis of evolutionary theory and genetics has enabled us to discover underlying molecular mechanisms of organismal evolution. We know that in order to maximize an organism's fitness in a particular environment, individual interactions among components of protein and nucleic acid networks need to be optimized by natural selection, or sometimes through random processes, as the organism responds to changes and/or challenges in the environment. Despite the significant role of molecular networks in determining an organism's adaptation to its environment, we still do not know how such inter- and intra-molecular interactions within networks change over time and contribute to an organism's evolvability while maintaining overall network functions. One way to address this challenge is to identify connections between molecular networks and their host organisms, to manipulate these connections, and then attempt to understand howsuch perturbations influence molecular dynamics of the network and thus influence evolutionary paths and organismal fitness. In the present review, we discuss how integrating evolutionary history with experimental systems that combine tools drawn from molecular evolution, synthetic biology and biochemistry allow us to identify the underlying mechanisms of organismal evolution, particularly from the perspective of protein interaction networks.
- Subjects
EVOLUTIONARY theories; GENETICS; ORGANISMS; NUCLEIC acids; SYNTHETIC biology; BIOCHEMISTRY
- Publication
Biochemical Journal, 2013, Vol 453, Issue 3, p311
- ISSN
0264-6021
- Publication type
Article