We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Melanin-Containing Hydrogel Intraocular Lenses: A Histopathological Study in Animal Eyes.
- Authors
Chirila, Traian V.; Constable, Ian J.; Vijayasekaran, Sarojini; Ben-Nun, Joshua
- Abstract
Poly(2-hydroxyethyl methacrylate) hydrogel intraocular lenses, containing adrenochrome-melanin, were manufactured and implanted in animal eyes in order to assess the effect of melanin upon (a) biocompatibility of implants with the eye tissues, and (b) fibrous proliferation of lens epithelium responsible for the opacification of the posterior capsular membrane. An equal number of control lenses were also implanted. The animals were followed up for durations up to two years, and a detailed histopathological examination of the eyes was performed subsequent to their enucleation. The postoperative complications were minor and probably caused by surgical trauma. The study failed to give any indication of the postulated antiproliferative activity of adrenochrome-melanin since minimal capsular opacification occurred in the operated eyes, regardless of the presence of melanin.
- Publication
Journal of Biomaterials Applications, 1995, Vol 9, Issue 3, p262
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/088532829500900305