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- Title
Approaches for Informing Optimal Dose of Behavioral Interventions.
- Authors
Voils, Corrine; King, Heather; Maciejewski, Matthew; Allen, Kelli; Yancy, William; Shaffer, Jonathan
- Abstract
Background: There is little guidance about to how select dose parameter values when designing behavioral interventions. Purpose: The purpose of this study is to present approaches to inform intervention duration, frequency, and amount when (1) the investigator has no a priori expectation and is seeking a descriptive approach for identifying and narrowing the universe of dose values or (2) the investigator has an a priori expectation and is seeking validation of this expectation using an inferential approach. Methods: Strengths and weaknesses of various approaches are described and illustrated with examples. Results: Descriptive approaches include retrospective analysis of data from randomized trials, assessment of perceived optimal dose via prospective surveys or interviews of key stakeholders, and assessment of target patient behavior via prospective, longitudinal, observational studies. Inferential approaches include nonrandomized, early-phase trials and randomized designs. Conclusions: By utilizing these approaches, researchers may more efficiently apply resources to identify the optimal values of dose parameters for behavioral interventions.
- Subjects
BEHAVIOR; A priori; CLINICAL trials; QUALITY of life; SURVEYS
- Publication
Annals of Behavioral Medicine, 2014, Vol 48, Issue 3, p392
- ISSN
0883-6612
- Publication type
Article
- DOI
10.1007/s12160-014-9618-7