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- Title
Clinical and Histologic Evaluation of Allogeneic Bone Matrix Versus Autogenous Bone Chips Associated with Titanium-Reinforced e-PTFE Membrane for Vertical Ridge Augmentation: A Prospective Pilot Study.
- Authors
Fontana, Filippo; Santoro, Franco; Maiorana, Carlo; Iezzi, Giovanna; Piattelli, Adriano; Simion, Massimo
- Abstract
Purpose: To compare clinically and histologically an allogeneic bone matrix to autogenous bone chips in the vertical ridge augmentation technique using titanium-reinforced e-PTFE membranes. Materials and Methods: The study protocol was designed to include patients with bilateral posterior mandibular partial edentulism. Patients were treated with a split-mouth design approach: each side was randomly assigned to the test group (titanium-reinforced e-PTFE membrane and allogeneic bone matrix) or to the control group (titanium-reinforced e-PTFE membrane and autogenous bone chips). Different clinical parameters including the amount of vertically regenerated bone (DSB) and biologic complications were recorded. Histomorphometric analysis and the bone-implant contact percentage were performed. Results: Five female patients were enrolled in the study. Ten edentulous sites were vertically augmented and 25 implants were inserted (13 test group, 12 control group) with a staged approach. In the test group no membrane was exposed. The mean bone regeneration was 4.70 mm (SD 0.48 mm). All 13 implants appeared clinically stable. In the control group, 1 membrane was exposed after 2 months. The mean crestal bone regeneration was 4.10 mm (SD 0.88 mm). All 12 implants were stable at the abutment connection. Nine biopsy specimens from the regenerated areas were evaluated. Vertical bone regeneration was evident in both groups since all the samples demonstrated trabecular bone with different degrees of maturation and mineralization in the regenerated area. Conclusion: Within the limits of this study based on 5 patients, it appears that the behavior of the allogeneic bone matrix is similar to that of autogenous bone chips when used for vertical ridge augmentation by means of guided bone regeneration techniques. Both grafts demonstrated analogous histologic characteristics. Nevertheless, long-term clinical studies are needed to confirm these preliminary results.
- Subjects
ARTIFICIAL implants; SURGICAL complications; AUGMENTATION mammaplasty; BIOLOGICAL membranes; BONES; BONE regeneration; PATIENTS; CONTROL groups; BIOPSY; EQUIPMENT &; supplies
- Publication
International Journal of Oral & Maxillofacial Implants, 2008, Vol 23, Issue 6, p1003
- ISSN
0882-2786
- Publication type
Article