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- Title
Gut hormones in the control of appetite.
- Authors
Murphy, K. G.; Bloom, S. R.
- Abstract
Obesity is one of the greatest threats to the health of the developed world. In order to design effective drugs to treat the alarming increase in obesity, it is essential to understand the physiology of normal appetite control and the pathophysiology of obesity. The hypothalamus interprets and integrates neural and humoral inputs to provide a coordinated feeding and energy expenditure response. Recent evidence suggests that certain gut hormones -- ghrelin, polypeptide YY, pancreatic polypeptide, glucagon-like-peptide 1 and oxyntomodulin -- have a physiological role in governing satiety via the hypothalamus. Gut hormone appetite-regulatory systems represent a potential target for the design of antiobesity drugs.
- Subjects
OBESITY; BODY weight; METABOLIC disorders; GASTROINTESTINAL hormones; NUTRITION disorders; PHYSIOLOGY
- Publication
Experimental Physiology, 2004, Vol 89, Issue 5, p507
- ISSN
0958-0670
- Publication type
Article
- DOI
10.1113/expphysiol.2004.027789