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- Title
Changes in serum DAMPs and cytokines/chemokines during near-infrared photoimmunotherapy for patients with head and neck cancer.
- Authors
Hiromasa Ishihara; Daisuke Nishikawa; Daisuke Muraoka; Katsuhiro Masago; Shintaro Beppu; Hoshino Terada; Hirokazu Matsushita; Nobuhiro Hanai
- Abstract
Background: Near-infrared photoimmunotherapy (NIR-PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR-PIT in real clinical settings. Methods: Seven NIR-PIT sessions were administered to five patients with head and neck squamous cell carcinoma (HNSCC). Serum damage-associated molecular patterns (DAMPs) (HMGB1 and Hsp70 levels), and cytokine and chemokine production, were compared before and after NIR-PIT. Results: The serum concentration of HMGB1 increased after NIR-PIT (p=0.031, Wilcoxon test) in all patients except one who did not achieve a clinical response. Chemokines MIP-1α (CCL3) and MIP-1β (CCL4) increased significantly 1–3days after treatment (CCL3, p=0.0036; CCL4, p=0.0016, Wilcoxon test). A low pretreatment neutrophil-to-lymphocyte ratio (NLR) was associated with a better response to therapy and survival. Conclusions: The release of DAMPs, and cytokine/chemokine production, were detected in the patients' peripheral blood. The baseline NLR may predict patient outcomes in response to NIR-PIT.
- Subjects
HEAD &; neck cancer; CHEMOKINES; NEUTROPHIL lymphocyte ratio; SQUAMOUS cell carcinoma; CYTOKINES
- Publication
Cancer Medicine, 2024, Vol 13, Issue 1, p1
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.6863