We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Preoperative systemic immune‐inflammation index as a significant prognostic factor after TURBT in patients with non‐muscle‐invasive bladder cancer: A retrospective study based on propensity score matching analysis.
- Authors
Ding, Li; Wang, Xiangbu; Deng, Xiaobin; Xia, Wentao; Wang, Kun; Yu, Xianlin; Huang, Yaotian; Wang, Junqi
- Abstract
Objective: To investigate the association of the preoperative systemic immune‐inflammation index (SII) with recurrence‐free survival (RFS) after transurethral resection of the bladder tumor (TURBT) of non‐muscle‐invasive bladder cancer (NMIBC) using propensity score matching (PSM) analysis. Methods: The clinicopathological characteristics and follow‐up data of NMIBC patients were collected retrospectively from two tertiary medical centers. A 1:1 PSM analysis was carried out using the nearest‐neighbor method (caliper size: 0.02). Cox regression analysis was used to identify the risk factors associated with RFS. Results: A total of 416 NMIBC patients were included in this study. Before and after matching, patients with increased SII had worse RFS (p < 0.0001 and p = 0.027, respectively). Multivariate Cox analysis identified SII as an independent predictor of RFS before (HR [95% CI]: 1.789 [1.232, 2.599], p = 0.002) and after matching (HR [95% CI]: 1.646 [1.077, 2.515], p = 0.021). In the matched subgroup analysis, an elevated SII had a significant association with postoperative worse RFS in the T1 stage (p = 0.025), primary status (p = 0.049), high‐grade (p = 0.0015), and multiple lesions (p = 0.043) subgroups. Conclusion: SII could accurately stratify the prognosis of NMIBC patients before and after PSM analysis. An elevated SII was significantly associated with worse RFS in NMIBC patients. Kaplan–Meier analysis for recurrence‐free survival in subgroups based on the systemic immune‐inflammation index (SII) after propensity score matching. SII accurately stratified between high and low risk groups of poor RFS in the T1 stage (p = 0.025), primary status (p = 0.049), high grade (p = 0.0015), and multiple lesion (p = 0.043) subgroups.
- Subjects
BLADDER cancer; PROPENSITY score matching; TRANSURETHRAL resection of bladder; CANCER invasiveness; PROGNOSIS; BLADDER obstruction
- Publication
Cancer Medicine, 2023, Vol 12, Issue 6, p7019
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.5501