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- Title
Fcγ receptors in the initiation and progression of systemic lupus erythematosus.
- Authors
Reefman, Esther; Dijstelbloem, Hilde; Limburg, Pieter C.; Kallenberg, Cees G.M.; Bijl, Marc
- Abstract
Summary Systemic lupus erythematosus, a systemic autoimmune disorder, is characterized by the production of autoantibodies to nuclear constituents and inflammatory lesions in multiple organ systems. Although the pathogenesis of the disease is largely unknown, recent studies have suggested that disturbances in apoptosis and/or clearance of apoptotic cells may play an important role in the induction and perpetuation of autoantibody production. When autoantibodies subsequently complex to autoantigens present on apoptotic cells, ligation of Fcγ receptor will result in inflammation and disease development. Indeed, mice deficient in activating Fcγ receptors were protected against inflammation in models of immune complex-mediated autoimmune disease, whereas deletion of the inhibitory Fcγ receptors increased autoantibody production and susceptibility to immune complex-induced inflammation. Additionally, functional polymorphisms in Fcγ receptors were shown to be associated with development of human systemic lupus erythematosus. This review focuses on the role of Fcγ receptors in the initiation of autoantibody production, inflammatory handling of immune complexes, and disease development in systemic lupus erythematosus.
- Subjects
SYSTEMIC lupus erythematosus; CELL receptors
- Publication
Immunology & Cell Biology, 2003, Vol 81, Issue 5, p382
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1046/j.1440-1711.2003.01188.x