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- Title
HLA- DP and γ-interferon receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection.
- Authors
Lam, Yuk‐Fai; Wong, Danny Ka‐Ho; Seto, Wai‐Kay; To, Kelvin Kai‐Wang; Hung, Ivan Fan‐Ngai; Fung, James; Lai, Ching‐Lung; Yuen, Man‐Fung
- Abstract
Background and Aim Studies show that polymorphisms in human leukocyte antigen ( HLA)- DP loci and certain γ-interferon ( IFN-γ) signaling pathway genes are related to persistence of hepatitis B virus ( HBV) infection and viral load in chronic HBV ( CHB) infection respectively. Our study aims to determine whether single-nucleotide polymorphisms (SNPs) linked to HLA-DP loci and IFN-γ signaling pathway are associated with HBV activities. Methods We compared the SNPs in the HLA- DPA1 gene (rs3077) and the IFN-γ receptor-2 gene (rs2284553 and rs9808753) of 100 treatment-naive hepatitis B e antigen ( HBeAg)-negative CHB patients with undetectable HBV DNA with 100 age- and sex-matched controls with HBV DNA > 2000 IU/m L. Results The median age of the study group was 47.9 years, and 61% were male patients. The distribution of the three polymorphisms was in Hardy- Weinberg equilibrium. Both rs3077 and rs2284553 polymorphisms were not associated with HBV viral load in terms of allelic frequency, genotypic frequency, dominant/recessive gene action. rs9808753 ( G allele) was associated with a reduced chance of 'undetectable HBV DNA' for patients below the age of 50 years in allelic frequency analysis (odds ratio 0.562; 95% confidence interval, 0.326-0.967; P value = 0.037). IFN-γ receptor-2 gene haplotype block (rs2284553/rs9808753) was not associated with HBV viral activity. Conclusion There was no significant association between HLA- DP polymorphism (rs3077) and IFN-γ receptor-2 gene polymorphism (rs2284553) with viral activity in HBeAg-negative CHB patients. Further studies are required to confirm the association between IFN-γ receptor-2 gene polymorphism (rs9808753) and reduced chance of having 'undetectable HBV DNA' in young CHB patients.
- Subjects
HLA histocompatibility antigen genetics; GENETIC polymorphisms; INTERFERON receptors; VIRAL hepatitis; HEPATITIS B -- Immunological aspects
- Publication
Journal of Gastroenterology & Hepatology, 2014, Vol 29, Issue 3, p533
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.12378