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- Title
Partial trisomy 11, dup(11)(q23q13), as a defect characterizing lymphomas with Burkitt pathomorphology without MYC gene rearrangement.
- Authors
Pienkowska-Grela, Barbara; Rymkiewicz, Grzegorz; Grygalewicz, Beata; Woroniecka, Renata; Krawczyk, Paulina; Czyz-Domanska, Katarzyna; Walewski, Jan
- Abstract
Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma characterized by specific morphological and immunophenotypic features. The basic genetic feature of BL is the rearrangement of MYC gene, visible as t(8;14)(q24;q32) translocation or its variant. However, some lymphomas with characteristic BL morphology are nowadays diagnosed as B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL (Inter-DLBCL/BL) for biological or clinical reasons. We present four lymphomas without the MYC rearrangement presented typical Burkitt morphology, FCM immunophenotype with some deviations when compared to a typical BL. The cases were finally diagnosed as Inter-DLBCL/BL. All of them presented a recurrent abnormality within the chromosome 11: dup(11)(q23q13). We suppose that the dup(11)(q23q13), in absence of the MYC gene rearrangement, is connected with borderline lymphomas with a morphology similar or identical to that of the Burkitt lymphoma. Identifying such an aberration may be helpful in the diagnostics of Inter-DLBCL/BL eventually forming a distinct subgroup of lymphomas.
- Subjects
TRISOMY; LYMPHOMAS; RETICULOENDOTHELIAL granulomas; BURKITT'S lymphoma
- Publication
Medical Oncology, 2011, Vol 28, Issue 4, p1589
- ISSN
1357-0560
- Publication type
journal article
- DOI
10.1007/s12032-010-9614-0