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- Title
Early menarche is associated with metabolic syndrome and insulin resistance in premenopausal Korean women.
- Authors
Lim, Se; Ahn, Ju; Lee, Jun; Kim, Dong; Seo, Ju-Hee; Lim, Jung; Lim, Se Won; Ahn, Ju Hyun; Lee, Jun Ah; Kim, Dong Ho; Lim, Jung Sub
- Abstract
<bold>Unlabelled: </bold>In pediatrics, identifying risk factors is important in planning the prevention of cardiovascular disease. The aim of this study was to determine whether there is an independent association between early menarche (<12 years) and metabolic syndrome (MetS) in Korean women. We analyzed data from 4463 premenopausal women from the Fourth Korea National Health and Nutrition Examination Survey-IV (2007-2009). MetS was defined by the International Diabetes Federation for Asians and insulin resistance (IR) was defined as HOMA-IR more than 3.05. The prevalence of MetS and IR was 7.9 and 15.0%. Women (55.6%) with MetS also showed IR. The prevalence of MetS was higher in both women with early menarche and late menarche (≥16 years) compared with the reference group (early, 12.8%; reference, 7.0%; late, 11.0%, both P = 0.002). However, the odds ratio for MetS was 3.54 (95% confidence interval (CI), 2.14-5.87) and for IR was 2.98 (95% CI, 1.99-4.47) after adjusting for age and other confounders such as lifestyle variables, reproductive variables and sociodemographic variables only in women with early menarche<bold>Conclusion: </bold>Early menarche was associated with an increased risk of MetS and IR in premenopausal Korean women.<bold>What Is Known: </bold>Early menarche is associated with higher risk of CVD-related death and all-cause mortality in Western studies. Early menarche is associated with higher risk of diabetes in Korean premenopausal women.<bold>What Is New: </bold>Early menarche (<12 years) is associated with metabolic syndrome and insulin resistance in nationally representative Korean premenopausal women. However, late menarche (>16 years) is not associated with metabolic syndrome after controlling for age and other confounders.
- Subjects
SOUTH Korea; MENARCHE; METABOLIC syndrome; INSULIN resistance; WOMEN; CARDIOVASCULAR diseases; OBESITY; ODDS ratio; AGE distribution; ASIANS; PERIMENOPAUSE; DISEASE prevalence
- Publication
European Journal of Pediatrics, 2016, Vol 175, Issue 1, p97
- ISSN
0340-6199
- Publication type
journal article
- DOI
10.1007/s00431-015-2604-7