We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Functional connectivity alterations associated with cognitive and motor impairment in Parkinson's disease.
- Authors
Kıçik, Ani; Bayram, Ali; Kurt, Elif; Erdoğdu, Emel; Işık, Esin Öztürk; Gürvit, Hakan; Demiralp, Tamer
- Abstract
Objective: Parkinson's disease (PD) has a heterogeneous cognitive profile and its pathophysiology has not been completely clarified. In this study, functional connectivity (FC) changes were investigated in PD patients and in PD subgroups classified according to cognitive and motor performance, using resting state functional magnetic resonance imaging (rs-fMRI) data. Methods: 55 PD patients diagnosed with PD according to the UK Brain Bank Diagnostic Criteria and 24 healthy controls (CH) matched for age, education and gender were enrolled in the study. Resting state fMRI data were collected using a 3T MR imaging device (Phillips, Achieva, The Netherlands) at Istanbul Medical Faculty. PD subgroups were generated using a clustering algorithm according to the scores of UPDRS-III, Stroop and Benton judgment of line orientation tests. Seed-based FC analysis was performed using the AAL3 atlas covering 112 seeds and CONN toolbox. Network-Based Statistics (NBS) method was used in the FC analysis to compare HC with the PD and with the PD sub-groups. Results: As a result of FC analysis, there was a significant decrease in FC between the somatomotor network (SMN) and visual regions in PD patients compared to the SC group (p<0.05, FWE-corrected). In the comparisons of PD subgroups and HC, PD patients with worse motor performance showed reduced FC in the SMN (p<0.05, FWE-adjusted); PD patients with worse visuospatial performance showed FC alterations at visual-SMN cortical connections in a subnetwork covering large visual regions (p<0.05, FWE-corrected). Conclusion: In our study, a significant decrease in FC was detected between SMN and visual regions in PD. These FC alterations indicate impaired visual-motor integration in PD. Moreover, our results also showed that besides the motor impairment in PD, the visuospatial impairment observed in PD causes increased visual-SMN disconnection. This study supported by TUBITAK #115S219.
- Subjects
FUNCTIONAL magnetic resonance imaging; PARKINSON'S disease; FUNCTIONAL connectivity; COGNITION disorders; DEEP brain stimulation; MAGNETIC resonance imaging; BANKING industry
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2023, Vol 17, p14
- ISSN
1307-8798
- Publication type
Article
- DOI
10.2399/ana.23.001s