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- Title
Transferring methadone-maintained outpatients to the buprenorphine sublingual tablet: a preliminary study.
- Authors
Greenwald, Mark K.; Schuh, Kory J.; Stine, Susan M.
- Abstract
There is no accepted algorithm to transfer opioid-dependent patients from methadone (METH) to its new alternative, buprenorphine (BUP). Five outpatients transferred (double blind, double dummy) from METH 60 mg/day (with one day at 45 mg) to BUP 8 mg s.l. tablet. Relative to METH maintenance, BUP decreased opioid agonist symptoms (transfer day 1) and increased withdrawal symptoms (days 1 and 2) and blood pressure (day 2). Self-reported heroin use did not increase from METH maintenance levels. It may be feasible to transfer outpatients on METH 60 mg/day to BUP 8 mg/day s.l. tablet, although this pilot protocol needs refinements to improve tolerability and clinical efficacy.
- Subjects
METHADONE treatment programs; DRUG abuse treatment; OPIOIDS; BUPRENORPHINE; HEROIN; OUTPATIENT medical care; CLINICAL trials; COMPARATIVE studies; DRUG withdrawal symptoms; RESEARCH methodology; MEDICAL cooperation; METHADONE hydrochloride; NARCOTICS; RESEARCH; RESEARCH funding; SUBSTANCE abuse treatment; PILOT projects; EVALUATION research; TREATMENT effectiveness; BLIND experiment; SUBLINGUAL drug administration
- Publication
American Journal on Addictions, 2003, Vol 12, Issue 4, p365
- ISSN
1055-0496
- Publication type
journal article
- DOI
10.1111/j.1521-0391.2003.tb00550.x