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- Title
DNA Sequencing in Adults With Acute Myeloid Leukemia to Detect Residual Disease Prior to Hematopoietic Cell Transplant—Reply.
- Authors
Gui, Gege; Dillon, Laura W.; Hourigan, Christopher S.
- Abstract
In multivariate analysis for the subset of patients with both targets at baseline (n = 317), persistence of either mutated I NPM1 i , I FLT3 i -ITD, or both detected in blood samples during remission prior to transplant was associated with increased relapse and worse survival (eFigure 11iiiA in Supplement 1).[1] Furthermore, patients testing positive for both mutated I NPM1 i and I FLT3 i -ITD had higher measurable residual disease (MRD) burden (median variant allele fraction approximately 6-fold higher) than those with detectable persistence of only 1 target. DNA Sequencing in Adults With Acute Myeloid Leukemia to Detect Residual Disease Prior to Hematopoietic Cell Transplant - Reply Comment & Response B In Reply b We thank Dr Khaire and colleagues for their interest in our study,[1] and for their agreement that the study provides strong evidence that the detection of persistent I FLT3 i -ITD or I NPM1 i variants in the blood samples of adults during first remission from AML prior to allogeneic transplant is associated with increased posttransplant relapse and death, compared with those testing negative.
- Subjects
ACUTE myeloid leukemia; DNA sequencing; ADULTS; CAPILLARY electrophoresis
- Publication
JAMA: Journal of the American Medical Association, 2023, Vol 330, Issue 2, p190
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2023.8653