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- Title
Neurodevelopmental Outcome of Extremely Low Birth Weight Infants from the Vermont Oxford Network: 1998â2003.
- Authors
Mercier, Charles E.; Dunn, Michael S.; Ferrelli, Karla R.; Howard, Diantha B.; Soll, Roger F.
- Abstract
AbstractBackground:Physicians and parents face significant uncertainties when making care decisions for extremely low birth weight (ELBW) infants. Many published estimates of death and developmental outcome are from well-funded university programs and may not reflect outcomes of infants from a variety of settings. The best estimates of the probabilities of death and severe disability combine local experience and published data. Objective:To describe the neurodevelopmental outcome of ELBW infants from centers of the ELBW Infant Follow-Up Group of the Vermont Oxford Network (VON) and to identify characteristics associated with severe disability. Methods:Predefined measures of living situation, health and developmental outcome were collected at 18â24 monthsâ corrected age for infants born from July 1, 1998 to December 31, 2003 with birth weights of 401â1,000 g at 33 North American VON centers. Logistic regression was used to identify characteristics associated with severe disability. Results:6,198 ELBW infants were born and survived until hospital discharge; by the time of follow-up, 88 infants (1.4) had died. Of the remaining 6,110 infants, 3,567 (58.4) were evaluated. Severe disability occurred in 34 of the assessed infants. Multivariate logistic regression suggested cystic periventricular leukomalacia, congenital malformation and severe intraventricular hemorrhage were the characteristics most highly associated with severe disability. There were marked variations among the follow-up clinics in the attrition rate. Conclusion:ELBW infants completing evaluation were at a high risk for severe disability. There are considerable differences among participating centers in attrition at follow-up. Further resources will be needed to study the effect of follow-up care for this group of infants.Copyright © 2009 S. Karger AG, Basel
- Subjects
LOW birth weight; DEVELOPMENTAL neurobiology; INFANT health; INFANT care; FOLLOW-up studies (Medicine); LOGISTIC regression analysis
- Publication
Neonatology (16617800), 2010, Vol 97, Issue 4, p329
- ISSN
1661-7800
- Publication type
Article
- DOI
10.1159/000260136