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- Title
An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide.
- Authors
He, Baoshan; Yan, Xiaohai
- Abstract
The authors constructed a voltammetric zearalenone (ZEN) aptasensor based on use of porous platinum nanotubes, gold nanoparticles (p-PtNTs/AuNPs) and thionine (Thi) labelled graphene oxide (GO). The p-PtNTs were synthesized in-situ based on tellurium nanowires as sacrificial templates. Subsequently, thiol-modified aptamers were self-assembled on the AuNPs that had been electrodeposited on the surface of the modified electrode. The presence of p-PtNTs on the electrode increases the loading with AuNPs and aptamers. It also warrants that the Thi-labelled GO can be assembled onto the aptamer via π interactions. In the presence of ZEN, it will be bound by the aptamer. The GO/Thi conjugate will be released from the aptamer, and this causes a decrease in Thi current. Under the optimal conditions and at a typical working potential of −0.22 V (vs. Ag/AgCl), the method has a linear range that covers the 0.5 pg·mL−1 to 0.5 μg·mL−1 ZEN concentraion range and a lower detection limit of 0.17 pg·mL−1.
- Subjects
GOLD nanoparticles; GRAPHENE oxide; NANOTUBES; PLATINUM nanoparticles; PLATINUM; DETECTION limit
- Publication
Microchimica Acta, 2019, Vol 186, Issue 6, pN.PAG
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-019-3500-z