We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Visceral adiposity index predicts the conversion of metabolically healthy obesity to an unhealthy phenotype.
- Authors
Kang, Yu Mi; Jung, Chang Hee; Cho, Yun Kyung; Jang, Jung Eun; Hwang, Jenie Yoonoo; Kim, Eun Hee; Lee, Woo Je; Park, Joong-Yeol; Kim, Hong-Kyu
- Abstract
Objective: Some individuals with metabolically healthy obesity (MHO) convert to metabolically unhealthy obesity (MUO) phenotype, and visceral adiposity is one of proposed mechanisms underlying such conversion. Visceral adipose index (VAI) is a novel mathematical model which estimates visceral adiposity based on anthropometric and lipid profiles. We aimed to determine the association of VAI-estimated visceral adiposity with the MHO-to-MUO conversion and the predictive value of VAI in estimating such unfavorable outcomes. Methods: A total of 2,204 Korean subjects with the MHO phenotype were enrolled and stratified by body mass index and metabolic health state according to Wildman criteria at baseline and last follow-up examinations. VAI was calculated at baseline. Results: Over a median follow-up period of 41.1 months, 46.0% of subjects converted to MUO phenotype. Higher VAI quartiles were associated with a greater proportion of subjects who underwent MHO-to-MUO conversion, and also with increased odds ratios for such conversion even after multivariate analyses. The optimal VAI cut off value was around 1.00, and VAI had a greater power in the prediction of MHO-to MUO conversion than waist circumference in both genders. Conclusion: MHO phenotypes with high VAI values are associated with poor future metabolic outcomes. VAI-estimated visceral adiposity is well correlated with the prognosis of MHO subjects, and VAI has a good predictive value in determining the MHO-to-MUO conversion.
- Subjects
OBESITY; PHENOTYPES; ANTHROPOMETRY; FOLLOW-up studies (Medicine); MATHEMATICAL models
- Publication
PLoS ONE, 2017, Vol 12, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0179635