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- Title
Collision-induced dissociation pathways of H-antihistamines by electrospray ionization quadrupole time-of-flight mass spectrometry.
- Authors
Do, Jung-Ah; Noh, Eunyoung; Yoon, Soon-Byung; Lee, Ji; Park, Sung-Kwan; Mandava, Suresh; Baek, Sun; Lee, Jongkook
- Abstract
Over the past decades, mass spectrometry technologies have been developed to obtain mass accuracies of one ppm or less. Of the newly developed technologies, quadrupole time-of-flight mass spectrometry (Q-TOF-MS) has emerged as being well suited to routine and high-throughput analyses of pharmaceuticals. Dietary supplements and functional foods have frequently been found to be contaminated with pharmaceuticals. In our continuous efforts to develop methodologies to protect public health against adulterated dietary supplements, we have constructed a mass spectral database for 21 H-antihistamines encountered as adulterants by using liquid chromatography-electrospray ionization (LC-ESI)/Q-TOF-MS, and have proposed their possible collision-induced dissociation pathways. This database will be very useful for the rapid and accurate detection of H-antihistamines (known) and their analogues (unknown) illegally added to dietary supplements as well as in other sample matrices.
- Publication
Archives of Pharmacal Research, 2017, Vol 40, Issue 6, p736
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-017-0921-2