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- Title
Significance of Preoperative Systemic Inflammation Score in Short-Term and Long-Term Outcomes of Patients with Pathological T2-4 Gastric Cancer After Radical Gastrectomy.
- Authors
Sato, Bin; Kanda, Mitsuro; Tanaka, Chie; Kobayashi, Daisuke; Iwata, Naoki; Hattori, Norifumi; Suenaga, Masaya; Hayashi, Masamichi; Yamada, Suguru; Murotani, Kenta; Fujiwara, Michitaka; Kodera, Yasuhiro
- Abstract
Background: Surgical resection is the mainstay of treatment for patients with gastric cancer (GC). Development of a simple, high-performance, integrated scoring system is needed to provide appropriate management. This study aimed to evaluate predictive values of the systemic inflammation score (SIS) for short- and long-term outcomes of patients who underwent surgery for GC.Methods: A total of 187 patients who underwent gastrectomy for pT2-4 GC without preoperative treatment were analyzed. SIS was formulated based on serum albumin level and lymphocyte-monocyte ratio, and graded into SIS 0, 1, and 2.Results: Preoperative SIS was significantly associated with incidence of postoperative complications, showing a stepwise increased incidence in proportion to SIS in the entire cohort and all subgroups according to operative procedure and disease stage. Overall and disease-free survival times of patients in SIS 0, 1, and 2 shortened in a stepwise fashion. SIS was linked to prevalence of hematogenous metastasis as initial recurrence site. Survival differences between patients with SIS 2 and the others were particularly large in patients who underwent adjuvant chemotherapy. The continuation rate of adjuvant S-1 was lower in the SIS 2 group.Conclusion: SIS represents a simple predictor for incidence of postoperative complications and survival in patients with pT2-4 GC.
- Subjects
GASTRECTOMY; STOMACH surgery; GASTRIC diseases; INFLAMMATION; DISEASE management; PATIENTS
- Publication
World Journal of Surgery, 2018, Vol 42, Issue 10, p3277
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-018-4597-7