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- Title
Quantitative Determinations of Duodenogastric Reflux, Prevalence of Helicobacter pylori Infection, and Concentrations of Interleukin-8 World J. Surg. Vol. 27, No. 5, May 2003.
- Authors
Fukuhara, Kenichiro; Osugi, Harushi; Takada, Nobuyasu; Takemura, Masashi; Ohmoto, Yasukazu; Kinoshita, Hiroaki
- Abstract
Billroth I or II reconstruction after distal gastrectomy often is associated with inflammation in the gastric remnant. We sought to determine which reconstructive procedure was most effective in preventing such remnant gastritis. Patients undergoing curative distal gastrectomy for cancer (n = 82) were classified as group A (Roux-en-Y, n = 22); group B (Billroth I, n = 40); or group C (Billroth II, n = 20). Interleukin (IL)-8 concentrations in gastric mucosa were measured 3 months after surgery. In the absence of Helicobacter pylori infection, IL-8 concentrations were 13, 56, and 87 pg/mg protein in groups A, B, and C, respectively (p < 0.05). In the presence of H. pylori infection, IL-8 concentrations were 61, 161, and 234 pg/mg protein in groups A, B, and C (p < 0.01). Roux-en-Y reconstruction is better able to prevent remnant gastritis than either the Billroth I or II procedure as judged from IL-8 concentrations in gastric remnant mucosa.
- Subjects
HELICOBACTER pylori infections; HELICOBACTER pylori; INTERLEUKIN-8; GASTRITIS
- Publication
World Journal of Surgery, 2003, Vol 27, Issue 5, p567
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-003-6796-z