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- Title
Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta‐analysis.
- Authors
Tsai, Yao‐Te; Kuo, Liang‐Tseng; Wang, Yun‐Ting; De Vito, Andrea; Hao, Sheng‐Po; Fang, Ku‐Hao; Lee, Yi‐Chan; Chen, Kuan‐Yin; Lai, Chia‐Hsuan; Tsai, Yuan‐Hsiung; Huang, Ethan I.; Tsai, Ming‐Shao; Hsu, Cheng‐Ming; Chang, Geng‐He; Luan, Chih‐Wei
- Abstract
We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random‐effects meta‐analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression‐free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.
- Subjects
HEAD &; neck cancer; OVERALL survival; SURVIVAL rate; PROGRESSION-free survival; CONFIDENCE intervals
- Publication
Head & Neck, 2024, Vol 46, Issue 8, p2086
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27842