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- Title
Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma.
- Authors
Bagué, Silvia; León, Xavier; Terra, Ximena; Lejeune, Marylène; Camacho, Mercedes; Avilés‐Jurado, Francesc‐Xavier
- Abstract
Background: To analyze the relationship between the transcriptional expression of lactate dehydrogenase A (LDHA) and the disease control in patients with a head and squamous cell carcinoma (HNSCC). Methods: We determined the transcriptional expression of LDHA in 110 HNSCC patients treated with surgery. Results: Five‐year disease‐free survival for patients with a high transcriptional expression of LDHA (n = 51) was 39.2% (95% confidence interval [CI]: 25.3%–53.1%), and for patients with a low expression (n = 59), it was 63.6% (95% CI: 51.1%–76.1%) (p = 0.004). According to the results of a multivariate analysis, patients with a high transcriptional expression of LDHA had a 3.4‐fold increased risk of tumor recurrence. Patients with a high transcriptional expression of LDHA tended to show a higher intensity of immunohistochemical expression of LDHA at the tumor cells (p = 0.086). Conclusion: In HNSCC patients treated with surgery, a high transcriptional expression of LDHA was associated with a significant decrease in disease‐free survival.
- Subjects
HEAD &; neck cancer; LACTATE dehydrogenase; SQUAMOUS cell carcinoma; OVERALL survival; PROGRESSION-free survival; MULTIVARIATE analysis
- Publication
Head & Neck, 2022, Vol 44, Issue 11, p2505
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27161