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- Title
Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer.
- Authors
Karsten, Rebecca T.; Al‐Mamgani, Abrahim; Bril, Sandra I.; Tjon‐A‐Joe, Sheena; Molen, Lisette; Boer, Jan P.; Hilgers, Frans J. M.; Smeele, Ludi E.; Brekel, Michiel W. M.; Stuiver, Martijn M.
- Abstract
Background: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long‐term functional swallowing impairment, such as feeding tube dependency. Methods: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT. Results: Sixty‐one patients (48%) became prolonged feeding tube‐dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02‐1.14, P =.01) adjusted for body mass index, abnormal diet, and socioeconomic status. Conclusions: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.
- Subjects
FEEDING tubes; HEAD &; neck cancer; SARCOPENIA; MUSCLE mass; BODY mass index
- Publication
Head & Neck, 2019, Vol 41, Issue 11, p4000
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25938