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- Title
Healthy human T-cell responses to Aspergillus fumigatus antigens.
- Authors
Kanafani, Zeina A.; Klepser, Michael E.
- Abstract
Aspergillus allergens are described as proteins that are recognized in patients with hypersensitivity syndromes such as allergic bronchopulmonary aspergillosis and Aspergillus-induced asthma. However, findings from this study indicate that (at least) some of these protein are not only allergens, but are also capable of inducing a T-helper 1 (Thl) cytokine response in volunteers without a history of suspected or proven fungal infection or reported allergy or atopy. This indicates that these "Asp f proteins" are able to induce both protective (Th and non-protective (Th2) inflammation.
- Subjects
T cells; PULMONARY aspergillosis; ALLERGIES; ASTHMA; ATOPY; ALLERGENS
- Publication
Journal of Invasive Fungal Infections, 2010, Vol 4, Issue 2, p69
- ISSN
1753-3783
- Publication type
Article