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- Title
The neuroscience and context of adolescent depression.
- Authors
Henje Blom, Eva; Ho, Tiffany C.; Connolly, Colm G.; LeWinn, Kaja Z.; Sacchet, Matthew D.; Tymofiyeva, Olga; Weng, Helen Y.; Yang, Tony T.
- Abstract
<bold>Unlabelled: </bold>Adolescent depression is a growing public health concern with an increased risk of negative health outcomes, including suicide. The use of antidepressants and psychotherapy has not halted its increasing prevalence, and there is a critical need for effective prevention and treatment. We reviewed the neuroscience of adolescent depression, with a focus on the neurocircuitry of sustained threat and summarised contextual factors that have an impact on brain development and the pathophysiology of depression. We also reviewed novel treatment models. <bold>Conclusion: </bold>Attention to the relevant neurocircuitry and contextual factors implicated in adolescent depression is necessary to advance prevention and treatment development.
- Subjects
DEPRESSION in adolescence; SUICIDE; NEUROSCIENCES; NEURAL circuitry; NEURAL development; PATHOLOGICAL physiology
- Publication
Acta Paediatrica, 2016, Vol 105, Issue 4, p358
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.13299