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- Title
A case of macroprolactinoma and elevated insulin-like growth factor-I in a young boy.
- Authors
Eyal, Ori; Naffaa, Lena; Elder, Deborah; Naffaa, Lena N; Elder, Deborah A
- Abstract
<bold>Unlabelled: </bold>We report a case of a 10-y-old boy who presented with persistent headache and was found to have a giant prolactinoma. Laboratory evaluation revealed markedly elevated prolactin (PRL) level, thyroid-stimulating hormone (TSH) deficiency, and elevated insulin-like growth factor-I (IGF-I). He had normal random growth hormone (GH) but non-suppressible GH during oral glucose tolerance test (OGTT). Cabergoline treatment was initiated and was well tolerated. Therapy successfully reduced PRL levels, normalized IGF-I levels, and reduced tumor size.<bold>Conclusion: </bold>Our patient presented with a GH-PRL-secreting tumor. Dopamine agonists are recommended as the treatment of choice for prolactinomas. However, there should be careful attention to GH status when treating GH-PRL-secreting tumor with dopamine agonists alone. IGF-I levels should be followed in all patients with prolactinoma, even in those with normal basal GH concentrations, because of the possibility of GH co-secretion.
- Subjects
HEADACHE in children; BOYS; PEDIATRIC diagnosis; JUVENILE diseases; PROLACTIN; PROLACTINOMA; THERAPEUTICS; PEDIATRIC neurology; PEDIATRICS; DIAGNOSIS; DISEASES
- Publication
Acta Paediatrica, 2005, Vol 94, Issue 12, p1852
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1080/08035250500268167