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- Title
Low-dosage ibopamine treatment in progressive renal failure: a long-term multicentre trial.
- Authors
Stefoni, Sergio; Mosconi, Giovanni; Manna, Gaetano La; Bonomini, Vittorio; Mioli, Vittorio; Fanciulli, Emilia; Feletti, Carlo; Docci, Dino; Cappelli, Paolo; Bonomini, Mario; Locatelli, Francesco; Marai, Paolo; Bazzato, Giorgio; Fracasso, Agostino; Brancaccio, Diego; Galmozzi, Celestina; Scarpioni, Lionello; Sverzellati, Enrico; Sorba, Gian Battista; Cossu, Maria
- Abstract
A multicentre trial (11 nephrology centres) was carried out to test the effects of ibopamine, an orally active dopamine-like drug, on the progression of chronic renal failure. For a 2-year period 189 chronic renal failure patients (serum creatinine level 1.5-4.0 mg/dl) were observed. They were homogeneous for basic nephropathy, degree of residual renal function, blood pressure, and proteinuria. The patients were randomly divided into two groups: 96 took ibopamine at a dosage of 100 mg/day (group A) and 93 served as controls (group B). All were on a low-protein diet (mean 0.8 g/kg body weight). By the end of the observation period, the rate of decrease of the renal function indexes in time proved significantly slower (1.8 times) in group A than in group B. The survival curves for renal function (pre-established end points were creatinine level increases equal to or > 20% and equal to or > 40% of the basal values) proved significantly better (p < 0.02 and p < 0.002 respectively) in group A than in group B. The mean plasma creatinine values rose by 17% in group A and by 36% in group B. The creatinine clearance decreased by 5% in treated patients and by 14% in the controls. Statistical analysis ruled out any possible centre effect. The trial suggests that low-dosage ibopamine administration may be used as a valid and safe pharmacological adjunct for retarding the progression of renal failure in patients with mild or moderate chronic renal impairment.
- Subjects
CHRONIC kidney failure; COMPARATIVE studies; CREATININE; DOPAMINE agonists; KIDNEYS; RESEARCH methodology; MEDICAL cooperation; REGRESSION analysis; RESEARCH; LOGISTIC regression analysis; EVALUATION research; RANDOMIZED controlled trials; DISEASE progression
- Publication
American Journal of Nephrology, 1996, Vol 16, Issue 6, p489
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000169049