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- Title
Diuretics in hypertension.
- Authors
Valvo, Enrico; D'Angelo, Angela; Maschio, Giuseppe
- Abstract
Despite the consistent reduction in the incidence of stroke and coronary events demonstrated in numerous clinical trials in young and elderly hypertensive subjects, the use of diuretics has declined as a first-line therapy in hypertension. The metabolic dose-dependent side effects and the increasing availability of new drugs appear the two main reasons for the decline. Although the neutral metabolic effects and the perception of a more physiological approach to hypertension has been advocated with the newer agents, no definite proof has been reported on the long-term effects on cardiovascular end-points. Many of adverse effects of diuretics can be limited by the use of low doses. For this reason, as well as their efficacy, safety, and cost-effectiveness, diuretics should remain a first-line therapy for hypertensive patients.
- Subjects
DIURETICS; HYPERTENSION; DRUG side effects; ANTIHYPERTENSIVE agents; DIURESIS
- Publication
Kidney International Supplement, 1997, Issue 59, pS-36
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1111/1523-1755.ep17697161